The College of Science was established as a branch of King Abdulaziz University in Tabuk in 1426 AH, according to the decision of the Higher Education Council and with the approval of the Custodian of the Two Holy Mosques, Prime Minister and Chairman of the Higher Education Council, and it was at that time including the mathematics and physics departments. Since the establishment of Tabuk University in 1427 AH, the College of Science has become one of its colleges.